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Notably, patients with minimal/mild endometriosis-associated infertility achieve lower success rates with stimulation and IUI compared to women with unexplained infertility, but ablation of minimal/mild endometriosis normalizes clinical pregnancy rates per cycle and cumulative birth rates, indicating that endometriosis exerts a reversible detrimental effect on fertility ( In vitro fertilization (IVF), including intracytoplasmic sperm injection (ICSI), is recommended for moderate-to-severe endometriosis, particularly in cases with ovarian endometriomas larger than 3 cm and/or deep infiltrating endometriosis, even when tubal patency and semen parameters are normal

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Burger-van Paassen N, Vincent A, Puiman PJ, van der Sluis M, Bouma J, Boehm G, van Goudoever JB, van Seuningen I, Renes IB

This is one of the reasons folic acid supplementation is widely recommended for women of reproductive age

Analogous to the experimental findings in rodents stated above, patients with GH-displaying mutations in the GH , GHR , and IGF1 genes present with reduced kidney sizes [127,128,129]