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In the former cells, peroxide in a time- and concentration-dependent manner disrupted actin filament organization that correlated with increased permeability, endocytosis, and transcytosis by promotion of cytoskeletal reorganization (Liu and Sundqvist, 1995)

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Animal data suggest subcutaneous routes required substantially higher doses than intravenous in rabbits, 1 mg/kg subcutaneous versus 25 mcg/kg IV, a 40-fold difference