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doi: 10.1189/jlb.0302105 51 RuckesTSaulDVan SnickJHermineOGrassmannR

Our pre-clinical findings provide rationale for the advancement of pharmacotherapeutic antioxidant treatments aimed at circumventing or perhaps reversing the deleterious effects of adolescent THC exposure

67 The negative role of IKK in inflammasome activation appears to involve induction of autophagy, an intracellular degradation system that maintains cellular homeostasis through degradation of abnormal proteins and damaged organelles like mitochondria

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For example, baicalein has been shown to attenuate multi-organ injury in inflammatory disease models by suppressing mitochondrial damage and mtROS generation, thereby preventing PANoptosome formation and inhibiting PANoptosis (Yuan T