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34 Furthermore, recent studies from Stuart Franks laboratory have shown that the GHR and prolactin receptor form complex heteromultimeric structures that may affect GH signal transduction in some cell lines

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4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied on in vitro mesangial cell models and lack validated animal models that fully recapitulate human IgA nephropathys pathological features (e.g., glomerular IgA1 deposition and mesangial proliferation)

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