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Research overwhelmingly describes the safety of GHK-Cu positively, such as when the authors of a 2018 review called it a safe, inexpensive, extensively studied compound.14 However, even though copper peptides have demonstrated an impressive safety track record in studies, there are (as with most skin care actives) a few safety risks to consider

Notably, the authors highlighted significant methodological limitations across the included studies, such as small sample sizes, short follow-up durations, and high heterogeneity in baseline selenium status, dosage regimens, and patient populations

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Unlike earlier coverage that focused on headlines (Category 2 removals and the July 2026 PCAC meeting), this follow-up zeroes in on the practical realities that will determine what happens next: API supply chain compliance and enforcement risk