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These compounds can be employed to disrupt the Cu reservation mediated by GSH-metallothionein so that dysfunction Cu homeostasis

Patel H, Chen J, Das KC, Kavdia M

By inhibiting the activity of the enzyme tyrosinase, glutathione can help to reduce skin discolouration such as freckles, age spots and hyperpigmentation

However, in hepatocellular carcinoma, the upregulation of NEAT1 leads to an increased level of myo-inositol oxygenase and enhanced ROS production, consequently increasing the sensitivity to ferroptosis [67]

GPX4, a fundamental regulator of ferroptosis, may convert GSH to oxidized glutathione and reduce lipid hydroperoxides to lipid alcohols