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The high expression of RB protein in tumor cells inhibits ferroptosis by interfering mitochondrial ROS production, while also inhibiting the efficacy of sorafinib

Flanagan TW, Nichols CD

Oncogene 43, 21042114

Conversely, when iron overload reflects an accumulation of labile, redox-active iron, this promotes ROS generation and lipid peroxidation, driving ferroptosis