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Vitamin B12, also known as cobalamin, is an essential nutrient that plays a key role in red blood cell production, nerve function, and DNA synthesis

33,206,211,222,223 DPN pathogenesis DPN is a complex neurodegenerative disorder resulting from the interplay of hyperglycemia-induced metabolic pathways, oxidative stress, inflammation, and dyslipidemia

Primary outcomes included changes in pain intensity (regarding low back pain and radicular leg pain) measured using the visual analogue scale (VAS), and functional improvement assessed by walking distance until symptoms appeared [63]

For oral administration, clinical trials have studied doses ranging from 1-30 mg daily, with typical protocols using 1-2 mg per dose on an empty stomach

Impact of NAFLD and its pharmacotherapy on lipid profile and CVD