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Plaque rupture leads to acute exposure of procoagulant and prothrombotic factors from the necrotic core of the lesion to platelets and procoagulant factors in the lumen, thereby causing thrombus formation (Figure 5) (168,169)

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PLoS Biol 2: e280 Mostafa YA, Taylor SD (2013) Steroid derivatives as inhibitors of steroid sulfatase