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HCC-associated SPOP mutants abrogate the inhibitory effect of SPOP-WT on KCNN3-induced progression in HCC via the CTCF-SATB1 axis To verify the effect of SPOP on KCNN3-induced EMT of HCC, we found that SPOP-WT inhibited KCNN3-induced HCC progression, which was eliminated in the KCNN3-SBC and SPOP-M35L/D153Y groups in vitro (Fig