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The major mechanisms by which the drug is cleaved from the antibody include hydrolysis in the acidic pH of the lysosomes (hydrazones, acetals, and cis-aconitate-like amides), peptide cleavage by lysosomal enzymes (the cathepsins and other lysosomal enzymes), and reduction of disulfides

CT scan of the kidneys, ureters and bladder - Most often the computerized tomographic (CT) scan is done without intravenous contrast first

Researchers typically use a standard insulin syringe, which is small and has a very fine gauge needle (usually 29-31g)

JAMA 268 (22): 3224-7, 1992