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Although we have extensive knowledge of the location of cysteine modifications in individual proteins, we lack a functional understanding and interplay of the various cysteine modifications in a single protein and their consequences on the global scale

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Acitretin, on the other hand, carries an increased risk of hepatotoxicity when combined with alcohol, as it converts into etretinate, the more toxic and persistent metabolite

This approach improves the delivery of therapeutics into CNS, as well as offers alternative approaches for the treatment of various neurodegenerative conditions