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As results showed from the systemic circulation, the introduction of FR and FA to the surface of nanoparticles promote brain accumulation

The MISEV2018 guidelines offer standardized recommendations to improve the rigor and reproducibility of EV studies, which include (i) considerations for EV separation/enrichment, (ii) EV characterization (e.g., size, concentration, morphology, molecular marker, protein content-based EVs, etc.), (iii) EV-associated and EV-excluded biological activities, and (iv) reporting standardsreporting the EV source, isolation, characterization, and experimental design (Thry et al., 2018)

TB-500 has been studied in humans with reported mild side effects such as headache and dizziness

[DOI] [Google Scholar] 50.Ritger P.L., Peppas N.A