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Moreover, three markers, namely rs12764057 (OR = 1.17, p = 1.19 10 8 ), rs10822974 (OR = 1.16, p = 1.65 10 7 ) and rs7903491 (OR = 1.10, p = 2.49 10 7 ), in the cell-adhesion molecule CTNNA3 gene were found to be statistically significant in the combined analysis of both stages [ 21 ]

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IR is present in 50%-70% of PCOS patients, and high insulin levels in the FF potentially directly stimulate the LH receptors on thecal cells, increasing their sensitivity to LH or reducing the hepatic production of sex hormone binding globulin (SHBG)

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Nevertheless, a particular advantage of these vaccines is that in addition to antibody and CD4 + T cell responses, DNA or RNA vaccine elicit CD8 + cytotoxic T cell responses, which plays a key role for virus eradication 41,42