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Thats the question I would ask if I was a patient. ___ AP video journalist Javier Arciga contributed to this story from San Diego.

In line with this, a study in rotating shift workers from the automotive industry found that NSW significantly reduced plasma concentrations of multiple immune markers, including pro- and anti-inflammatory cytokines (TNF-, IL-2R, IL-1RA, IL-4, IL-12, IL-17), chemokines (IP-10, MIP-1, MIP-1, RANTES), and growth factors (EGF, FGF, VEGF), indicating a broad suppression of immune pathways linked to circadian disruption and higher susceptibility to infection and cancer 113

In the MRL/Fas(lpr/lpr) lupus mouse model, this mechanism significantly ameliorates disease manifestations and extends survival (157)

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officinarum was shown to possess an anti-inflammatory effect in LPS-activated mouse RAW 264.7 macrophages and human PBMCs in vitro (Yadav et al., 2003) HMP at the concentration range of 6.2525 M significantly reduced the NO level in the mice macrophages and IL-1 and TNF- levels in PBMCs in a dose-dependent pattern