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Khanduri, U., & Sharma, A

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In trans -signaling, circulating IL-6 binds to sIL-6Rs to form a complex, then binds with the gp130 dimer that is expressed on almost all cell types

According to further features in preferred embodiments of the invention described below provided is a pharmaceutical composition for therapeutically or prophylactically treating an individual known to have a central nervous system neurodegenerative disorder associated with oxidative stress, the composition comprising a compound, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the individual