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A similar effect was observed for those encoding the iron permeases fepC (+ 3.7), sirA (+ 2.2), fhuB (+ 1.9), sstB (+ 1.8), and htsB (+ 1.4)

Increased production of ROS increases oxidative stress and therefore promotes apoptosis via multiple caspase pathways in PTECs upon exposure to high glucose (89, 90)