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Both endogenous and exogenous compounds can induce xCT up-regulation in the plasma membrane [31,32,33]

Subcutaneous injection over the buttock area

Lymph sparing liposuction with generous tumescent technique that avoids general anesthesia Generally not more than 5.0 liters of total volume aspirate should be removed in one surgical procedure Generally not more than 5% 8% of total body surface area should be treated in one surgical procedure Small liposuction cannulas should be used Surgical technique is very important

Inhibition of non-c-Met targets may enhance the antitumor activity of non-selective c-Met inhibitors, but is also correlated with increased toxicity and limits the dose so that inhibitors cannot effectively suppress c-Met (Bouattour et al., 2018)