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Description

The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

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Retatrutide an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously represents the cutting edge of obesity biology research as of 2026