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The CNS is especially susceptible to oxidative damage (Nunomura et al., 2006), motor neurons are highly sensitive to OS (Simpkins and Dykens, 2008) and the CNS has a poor antioxidant capacity with low activity of protective enzymes such as glutathione peroxidase (GPx), catalase (CAT) or superoxide dismutase (SOD) and poor capacity for cell regeneration (Kim et al., 2015

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Moreover, the reduced form of GSH directly detoxifies ROS and controls the activities pertaining to GSH dependent ROS and MG detoxifying enzymes 9,53

The harmonious balance between oxidants and antioxidants is vital to sustaining cellular functions critical for longevity