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Your doctor may recommend you have a Whipple procedure to treat: Pancreatic cancer Pancreatic cysts Pancreatic tumors Pancreatitis Ampullary cancer Bile duct cancer Neuroendocrine tumors Small bowel cancer Trauma to the pancreas or small intestine Other tumors or disorders involving the pancreas, duodenum or bile ducts The goal of doing a Whipple procedure for cancer is to remove the tumor and prevent it from growing and spreading to other organs

The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer

Adv Mater 26(5):805809

Table 1 Role of kinases in OR desensitization/tolerance

mtROS-mediated oxidative damage results in cysteine residues within the mitochondrial calcium uniporter (MCU) becoming cysteinylated with S-glutathione, assembling the MCU channel into persistently active higher-order complexes, and promoting sustained mitochondrial calcium uptake [92]