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In contrast, we observed an increase basal coronary blood flow, which is in accordance with observations in humans with diabetes and CKD [35, 43, 50], but also patients with HFpEF in general [1] and is likely to be explained by the hearts heightened metabolic and oxygen demands imposed by elevated cardiac after- and/or preload [2]

17 , 23 PK enzyme activity is red cell age-dependent, and so cases of suspected PKD with a normal PK enzyme assay should also be evaluated further via calculation of the PK/hexokinase ratio

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