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Effect of semaglutide was weaker than that of tirzepatide

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Endocr Rev (1992) 13:16491

In vitro, KYNA protects cortical neurons from reactive glia- and QA-induced atrophy, enhancing neurite complexity and synapse formation, indicating that increasing KYNA or inhibiting glial KP activity can mitigate excitotoxic and inflammatory neuronal damage [86]

Cells were run on a BD FACS Canto II flow cytometer and the data were analyzed with FlowJo 10.0.7 (Tree Star)