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As summarized in Table 4, preclinical and clinical studies support cardioprotective effects of metformin across diverse cardiac conditions, but large, rigorously designed trials are needed to define its role beyond metabolic indications

Also, measures of G6PD activity are generally reflective only of the amount of enzyme, rather than the activity within the cell, because at physiological concentrations of NADPH, G6PD is almost completely inhibited (22)

Importantly, the 9-me-BC-treated rats were otherwise healthy, meaning that the results of the study can be extrapolated to potential nootropic efficacy in healthy humans, rather than, as is often the case, surmising potential effects based off of studies normally performed in either animal models of cognitive disorder, or in humans with reduced mental function

Some IBS cases are tied to gut-brain signaling and pain sensitivity

How do we get it then