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The indirect role of ADH5 in NO homeostasis has prompted the development of pharmacological inhibitors that might be used for the treatment of inflammatory diseases 50

These authors demonstrated that DEM treatment strongly activates p21 showing a clear inhibition of cell proliferation

At this level, it leads to dysfunction following the production of ROS due to its binding to MTs, which are responsible for maintaining zinc homeostasis and free radicals scavenging (70, 71)

doi:10.1016/j.redox.2018.101084 Shyer JA, Flavell RA, Bailis W

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