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Consistent with this hypothesis, interrogation of our gene expression microarray data sets revealed increased expression of several JNK regulatory genes including the toxicity and JNK inducer TAJ ( TNFRSF19 , 8.33-fold, adjusted P -value 1.25 10 18 , Supplementary Table 1), and JNK target genes including the p53-inducible proteins TP53I3 ( PIG3 , 5.02-fold, adjusted P -value 1.73 10 16 ) and CDKN1A ( p21 , 4.87-fold, adjusted P -value 9.62 10 15 ) in GSTP1 knockdown cells

doi: 10.1016/j.ajpath.2012.09.016 194 LeeFTCaoZLongDMPanagiotopoulosSJerumsGCooperMEet al

10.1183/16000617.0021-2019 126 SongX.TanL.WangM.RenC.GuoC.YangB.et al (2021)

ATF-2, Activating Transcription Factor 2

These ROS damage nucleic acids, lipids, and proteins, triggering various adverse cellular effects, including termination of cell division