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However, a cavity on the capsid surface at an inter-protomer interface, where we previously reported extra electron density 7 , has recently been identified as potentially druggable, with micro-molar binding for a benzene-sulfonamide derivative 8

The effect of ATM-deficiency on H 2 O 2 -sensitivity was confirmed in a CII-isogenic cell line with stable knockdown of ATM ( Online Supplementary Figure S7A )

In recent years, accumulating evidence suggests that oxidative stress, mitochondrial dysfunction, and disturbances in iron homeostasis serve as upstream triggers driving these pathological cascades (Luo et al., 2019

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An endoperoxide reactivity-based FRET probe for ratiometric fluorescence imaging of labile iron pools in living cells