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Metabolic Pharmaceuticals' Phase 2 clinical trial tested multiple doses (1mcg/kg up to 400mcg/kg, as well as fixed doses of 1mg/day) in obese patients

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median placebo : 386 mol/L, P 0.68) (Table 2B)

Hydroxy B12 is considered one of the most well-tolerated forms of vitamin B12, offering sustained release and potentially longer-lasting benefits compared to other forms like cyanocobalamin

In mammals, PPP occurs in the cytoplasm of cells in various organs, including the liver, mammary glands, and adrenal glands, where it plays a vital role in generating high levels of NADPH required for biosynthetic processes (Figure 2) (Warburg and Christian, 1931