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Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

They did not show narrowing of the blood vessel lumen

3 The L-NAME Interaction: A Mechanistic Proof of Concept The L-NAME experimental paradigm deserves specific attention because it constitutes the clearest mechanistic evidence for NO pathway dependency

If you want to understand the science more deeply, Understanding How Liposomal Glutathione Works is a useful companion read

The correlation between objective nerve measurements and subjective symptom improvement strengthened confidence in the mechanism