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We also discuss potential metabolic approaches to improve the efficacy and persistence of CAR-T cells, providing a new strategy for the clinical application of CAR-T cell therapy

[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Mitchell J, Kim SJ, Koukos G, Seelmann A, Veit B, Shepard B, Blumer-Schuette S, Winter HS, Iliopoulos D, Pothoulakis C, et al

Results Chronic loss of IF1 supports a model of increased resting m To define the suitability of using cells depleted of IF1 as a model of chronic mitochondrial hyperpolarization, we started by characterizing the resting m of HEK293 IF1-KO relative to the isogenic WT counterparts 13

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Liver Failure Symptoms Early signs of liver damage The early symptoms of liver failure are often similar to those of other conditions