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First-generation copper chelators, including the 8-hydroxyquinoline derivative CQ, have shown efficacy in preclinical models by redistributing metal ions within A plaques, reducing A-induced neurotoxicity and improving cognitive performance in transgenic mouse models of AD (240)

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This paper demonstrates that c-Myb transcriptionally regulates CDO1 and inhibition of CDO1 expression upregulates GPX4 (Hao et al., 2017)

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