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Abbreviations ASCA anti- Saccharomyces cerevisiae antibody FGID functional gastrointestinal disorders GF germ-free IEB intestinal epithelial barrier IBD inflammatory bowel disease IBS irritable bowel syndrome IBS-C constipation-predominant irritable bowel syndrome IBS-D diarrhea-predominant irritable bowel syndrome IBS-M irritable bowel syndrome with mixed bowel habit LPS lipopolysaccharides SCFA short-chain fatty acids

During drug discovery, the drug-likeness and rule of five proposed by Lipinski (2004) predict that poor absorption is more likely to happen if the drug does not exceed 5 hydrogen bonds (2 in FA) and 10 H-bond acceptors (3 in FA)

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A lack of vitamin C can lead to scurvy, a condition characterized by symptoms like bleeding gums, joint pain, and fatigue

Aug 1 2019;110(2):316-329