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The main causes of a vitamin B12 deficiency are as follows: Malabsorption due to poor intestinal health (inflammation, bacteria, fungal infection, parasites, disturbed intestinal flora) due to a lack of transport molecules (intrinsic factor), genetic diseases (cobalamin disease) or medications that hinder uptake

Furthermore, in neuron-specific Slc25a39 knockout mice, FGF21 was unable to exert its neuroprotective effects

Durn N, Justo GZ, Melo PS, De Azevedo MBM, Souza Brito ARM, Almeida ABA, Haun M (2003) Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with -cyclodextrin