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33 ) but also an altered GSH conjugation pathway, an important cell detoxification mechanism, showing significantly increased expression of genes associated with this pathway (15 genes out of 36 were affected

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In addition, as these mutants are affected in glutathione biosynthesis they would respond less efficiently than the WT to an increased demand for glutathione as a consequence of the AITC treatment

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Ras/AP-1 signaling pathway The RAS superfamily of GTPases (Fig