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In future perspectives, augmenting CAR-T cell efficacy, increasing resist immunosuppressive TME, overcoming antigen loss and heterogeneity, metabolic reprogramming, avoiding the CAR-T cell exhaustion and immunological synapse dysfunction, improving tumor site trafficking and infiltration, and importantly restricting the CAR, adverse events should be considered as major goals for researchers' efforts in this field

Then she saw the toxicology report

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At the same time, in the treatment of NAFLD and non-alcoholic steatohepatitis [139, 140], nanoparticles encapsulated living bacteria can affect liver lipid metabolism and inflammatory response by improving intestinal flora imbalance and regulating the production of intestinal metabolites, such as SCFAs

To increase the NADH/NAD + ratio, the citric acid cycle is very sensitive