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Additionally, the immunosuppressive effects of diclofenac sodium, which were manifested by decreased phagocytic activity, phagocytic index, and a significant decrease in the titer of antibodies formed against NDV were significantly reversed by oral supplementation of broiler chicks with Spirulina at a dose of 10 gm/kg in their diet, either on therapeutic or preventive regimes (44)

In addition, ROS stabilize and enhance hypoxia-inducible factor-1 (HIF-1), the oxygen-sensitive subunit of the HIF-1 transcription factor, by inhibiting prolyl hydroxylasemediated degradation under both hypoxic and inflammatory conditions

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In particular, the relative abundance of Bacteroidetes decreased, whereas Firmicutes increased until 12 months post-eradication, leading to a shift in the Bacteroidetes/Firmicutes ratio, which is associated with obesity

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