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MTs are cysteine-rich proteins that regulate Zn and copper homeostasis, are involved in heavy metal detoxification (such as cadmium and mercury), alleviate oxidative/nitrosative stress, and participate in immune responses [331]

3a rather than H-site (ASP101, GLN67, THR68, PRO56, TYR9, GLN54, VAL55, ARG131, ARG45, PHE220) as expected from X-ray data shown in Fig

Finally, we outline translational prospects, arguing that targeting this pathway will require precision medicine strategies, including composite biomarkers and rational combination therapies

James et al., 2023)

Persistent hyperglycemia in diabetes induces oxidative stress via mitochondrial dysfunction and subsequent enhanced reactive oxygen species (ROS) production