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Consistency and the right dosage are key to long-term results

In Nrf2-knockdown cells, the inhibitory effects of LicoA on cellular ROS and lipid peroxidase levels were largely abolished (Figures 6AE), and its regulatory effects on transferrin receptor, GPX4, and xCT were nearly eliminated (Figures 6FH)

Antioxid Redox Signal 17(4):534543 S Darvesh A, Bishayee A (2010) Selenium in the prevention and treatment of hepatocellular carcinoma

The obtained results indicate that high seed vigour related to the mode of action of NO and its derivatives is closely linked to the maintenance of higher GSH levels