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A2M binds to and inactivates the destructive enzymes that break down cartilage, helping to slow joint degeneration, relieve pain, and protect against further damage from osteoarthritis

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Noticeably, synaptamide, a DHA metabolite analog of the endocannabinoid anandamide, ameliorates cAMP signaling and boosts the NSC differentiation impaired by ethanol (46) (Figure 2)

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