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The images (Figure 5) showed a time-dependence penetration into the skin, as initially, the particles tended to penetrate between the corneocytes isles (green stained) and, further application time, the vesicles tended to penetrate via intercellular lipids and follicular regions (red stained) until a maximum depth of 60 m [57]

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In summary for LCMS single and tandem/hybrid MS systems, TQ MS (MRM mode) ranks first, followed by TOF MS and then single quadrupole MS (SIM) mode in terms of quantitative analysis performance (e.g

pH stability of TAT-CcSOD1 was determined by measuring the residual activity in buffers with different pH values (ranging from 3.0 to 11.0)