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Evidence quality: Strong

In bleomycin-induced pulmonary fibrosis, melatonin reduces the infiltration and accumulation of inflammatory cells in the alveolar walls (111), as well as the expression of inflammatory mediators such as cyclooxygenase 2 (COX-2) (78)

What makes it unique is its ability to affect multiple systemsmusculoskeletal, gastrointestinal, and nervousoften without the inflammatory delay common with other healing compounds

The tirzepatide molecule is actually slightly more sensitive to temperature fluctuations than semaglutide, which is why Mounjaro has a shorter room-temperature window (21 days) compared to Ozempic (56 days)

Accordingly, for lower demand patients, a conservative approach may be most suitable