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Acquired PGA elevation can also occur during chronic acetaminophen use [67, 68] as acetaminophen metabolism consumes glutathione through conjugation reactions, thereby depleting GSH stores and increasing metabolic flux toward PGA formation [69]

Beyond these blood markers, resmetirom also demonstrated some positive effects on liver health

Some report that their migraine returns within 24 to 72 hours, which is part of why dexamethasone is sometimes included

R For COMT Met/Met patients, methylation support (adequate B vitamins , magnesium , and SAM-e if tolerated) helps compensate for the reduced enzyme activity

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