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Key questions remain regarding its ability to effectively inhibit NLRP3 inflammasome activation within the complex milieu of diabetic lung injury, and whether long-term suppression of this core innate immune pathway might lead to the activation of compensatory inflammatory pathways or other unknown off-target effects, all of which require longer-term clinical investigation

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10.21769/BioProtoc.2774 48 ZhiD.WangD.YangW.DuanZ.ZhuS.DongJ.et al (2017)

Effect of agonists and antagonists of cholinergic neurotransmission on growth hormone release in the dog