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Redox sensing and signalling associated with reactive oxygen in chloroplasts, peroxisomes and mitochondria

This discovery arose from an appreciation that angiogenesis of the retina of new-born animals was related to the development of local hypoxia in the retina driving the production of VEGF (67, 68)

1 ROS-mediated damage has been cited as a probable contributing cause for many common neurodegenerative diseases, suggesting that the natural antioxidant defence mechanisms are overwhelmed in these cases