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Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30

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The results presented here are consistent with earlier findings in 2D BC cell culture, which demonstrated that high concentrations of Vit-C led to significant cellular cytotoxicity and morphological disintegration [22, 25, 36, 37]

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Nighttime blood pressure phenotype and cardiovascular prognosis: Practitioner-based nationwide JAMP study