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The prediction of future conversion to MCI over 15 years is unlikely to be explained by undiagnosed cognitive impairment, placing changes detected by these aging models early in the causal chain of cognitive decline and neurodegenerative disease

Unlike conventional therapeutics, NADs induce long-lasting or curative effects due to their distinct physicochemical and biological properties

It must be noted that the specific probiotic effects described in the literature are based upon specific probiotic species, strains, combinations, and dosages

For example, sulforaphane attenuated cell necrosis and apoptosis in renal injury rats 51 and type 1 diabetes mice 52 models