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The role of cGAS-STING in age-related diseases from mechanisms to therapies

10.1038/s41746-025-01549-7 107

doi: 10.1007/s10571-023-01383-z, [DOI] [PMC free article] [PubMed] [Google Scholar] 93.Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, et al

This was done by replacing the 3,4,5-trimethoxyphenyl moiety at R 1 with several heteroarylmethylamino and hydroxylamine groups, as it was proven in the same study that the 3,4,5-trimethoxyphenyl at R 1 is not crucial for PDE5 inhibitory activity