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This repeated oscillation applies mechanical forces (sound pressure) to the endothelial cells of the BBB, loosening the tight junctions and briefly opening the barrier

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More than 25 years were required to achieve these goals, which were made possible by the characterization, isolation, size reduction, and blending of the -globin locus regulatory elements and the advent of lentiviral vectors, which can transfer complex sequences into hematopoietic stem cells