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However, its high sensitivity in detecting minimal residual disease (MRD) may lead to lower CR response rates, thus hindering comparisons with results obtained by immunofixation at different time points or in other studies [56]

Conversely, low HDI regions had fewer cases (109,572) but extremely high mortality (58,586 deaths) ( Table 2 ), with a mortality-to-incidence ratio more than double that of high HDI regions ( Table 2 Breast cancer burden across human development index (HDI) levels

The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types

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