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At standard doses, naltrexone functions as an opioid receptor antagonist used for addiction treatment, but at significantly lower doses (typically 1.5-4.5mg), it exerts unique effects on immune regulation and inflammatory pathways that appear beneficial for autoimmune conditions

doi: 10.1038/s41584-018-0058-9 30 DonatoRCannonBRSorciGRiuzziFHsuKWeberDJet al

Haithcock D, Jiao H, Cui XL, Hopfer U, Douglas JG

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The Naloxone Challenge Test for Recreational Drugs Before LDN Treatment The naloxone challenge test helps medical personnel determine if someone has opioids in their system before starting low-dose Naltrexone, as its introduction can cause sudden, dangerous withdrawal if opioids are present